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MYP_121943
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Basic Information
Antimicrobial peptide M
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
31 amino acids
C144H237N39O39S2
Standard
Sequence
ALWKTMLKKLGTMALHAGKAAFGAAADTISQ
Physicochemical Analysis
3202.79 Da
10.00
2.88
2.63
0.0929
0.32
0.51
0.22
6.23
88.71
0.0645
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1246.18
-10.94
44.0
45.0
108.0
224.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016603 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa distincta [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0029501 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa distincta [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis
38 μM
MIC
PMID10477123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10477123/
RECORD: Rec_0043432 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa distincta [Animal]
Dermadistinctin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
9.7 μM
MIC
PaperC.V. Batista et al. / Peptides 20 (1999) 679-686. Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta Evidence URLhttps://www.uniprot.org/uniprotkb/P83640/entry
RECORD: Rec_0076403 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa distincta [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
38 μM
MIC
PaperAntimicrobial peptides from the Brazilian frog Phyllomedusa distincta.
RECORD: Rec_0089710 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa distincta [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Non-ribosomal
Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus
Qualitative functional evidence
PMID18644413 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18644413/; https://www.uniprot.org/uniprotkb/P83640/entry; https://bblserver.org.in/ampdb/
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