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MYP_121868
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Basic Information
M2 AH
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H1N1
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
18 amino acids
C111H165N31O22S
Standard
Sequence
RLFFKCIYRFFEHGLKRG
Physicochemical Analysis
2317.76 Da
10.30
3.84
3.56
0.2132
-0.24
0.81
-0.11
-9.57
65.00
0.2778
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
881.97
-3.23
34.0
28.0
77.0
165.0
6.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0251338 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
MDCK cells; Influenza A virus H1N1 (A/Puerto Rico/8/34)
H1N1 inhibition and MDCK cytotoxicity assays (qualitative summary record)
PMID31375212 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31375212/
RECORD: Rec_0293041 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Madin-Darby canine kidney epithelial (MDCK) cells
70 μM
CC50 / cell viability assay
PMID31375212 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31375212/
RECORD: Rec_0302746 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Influenza A virus H1N1 (A/Puerto Rico/8/34); MDCK cells
0.87 μM
IC50
PMID31375212 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31375212/
RECORD: Rec_0328629 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-H1N1 Infection inhibition
Influenza A virus H1N1 (A/Puerto Rico/8/34); MDCK cells
0.87 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperEnvelope-deforming antiviral peptide derived from influenza virus M2 protein. | Jung Y, Kong B, Moon S, Yu SH, Chung J, Ban C, Chung WJ, Kim SG, Kweon DH. | Biochem Biophys Res Commun. 2019 Sep 24;517(3):507-512. | DOI:10.1016/j.bbrc.2019.07.088 | PMID:31375212 PMID31375212 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31375212/