‹ ›
MYP_121868
← PREVIOUS NEXT → BACK
Basic Information
M2 AH
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H1N1
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
18 amino acids
C111H165N31O22S
Standard
Sequence
RLFFKCIYRFFEHGLKRG
Physicochemical Analysis
2317.76 Da
10.30
3.84
3.56
0.2132
-0.24
0.81
-0.11
-9.57
65.00
0.2778
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
881.97
-3.23
34.0
28.0
77.0
165.0
6.0
17.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0251338 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID31375212 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31375212/
RECORD: Rec_0293041 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Madin-Darby canine kidney epithelial(MDCK) cells:CC50=70
PMID31375212 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31375212/
RECORD: Rec_0302746 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
H1N1(A/Puerto Rico/8/34):inhibition of infection in Madin-Darby canine kidney epithelial(MDCK) cells
0.87 μM
IC50
PMID31375212 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31375212/
RECORD: Rec_0328629 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-H1N1 Infection inhibition
H1N1 (A/Puerto Rico/8/34)
0.87 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperEnvelope-deforming antiviral peptide derived from influenza virus M2 protein. | Jung Y, Kong B, Moon S, Yu SH, Chung J, Ban C, Chung WJ, Kim SG, Kweon DH. | Biochem Biophys Res Commun. 2019 Sep 24;517(3):507-512. | DOI:10.1016/j.bbrc.2019.07.088 | PMID:31375212 PMID31375212 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31375212/