Peptide Database

Peptide NameM-theraphotoxin-Gr1a (M-TRTX-Gr1a) (GsMTx-4) (GsMTx4) (MTx4) (GsMTx-IV)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length82 amino acids

Chemical FormulaC424H659N107O118S8

DescriptionStandard

        MKTSVVFVIAGLALLSVVCYASELKEQSSVNEVLSTIFHFEQPEERGCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSFGK
    

Molecular Weight9399.93 Da

Isoelectric Point (pI)8.18

Net Charge (pH 7.0)1.53

Net Charge (pH 7.4) 1.13

Charge Density (pH 7.0) 0.0187

GRAVY Index0.00

Hydrophobic Moment 0.52

Boman Index0.05

Instability Index27.10

Aliphatic Index 80.73

Aromaticity 0.1220

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3629.06

LogP -30.02

H-bond Donors 131.0

H-bond Acceptors 129.0

Rotatable Bonds 314.0

Heavy Atoms 657.0

Ring Count 16.0

Amide Bonds 87.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0009611 VERIFIED: YES

Provenance & Taxonomy

OrganismGrammostola rosea [Animal]

FamilyNeurotoxin 10 (Hwtx-1); 52 (MTx4) subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetS. epidermidis (Gram-positive)

RECORD: Rec_0165089 VERIFIED: YES

Provenance & Taxonomy

OrganismGrammostola rosea [Animal]

FamilyNeurotoxin 10 (Hwtx-1); 52 (MTx4) subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetS. typhimurium

RECORD: Rec_0230378 VERIFIED: YES

Provenance & Taxonomy

OrganismGrammostola rosea [Animal]

FamilyNeurotoxin 10 (Hwtx-1); 52 (MTx4) subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0287457 VERIFIED: YES

Provenance & Taxonomy

OrganismGrammostola rosea [Animal]

FamilyNeurotoxin 10 (Hwtx-1); 52 (MTx4) subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)

RECORD: Rec_0359302 VERIFIED: YES

Provenance & Taxonomy

OrganismGrammostola rosea [Animal]

FamilyNeurotoxin 10 (Hwtx-1); 52 (MTx4) subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetAeropyrum pernix

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