Peptide Database

Peptide NameMT-SC24EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length26 amino acids

Chemical FormulaC151H236N34O49S

DescriptionStandard

        MTWEEWDKKIEEYTKKIEELIKKSEE
    

Molecular Weight3343.75 Da

Isoelectric Point (pI)4.82

Net Charge (pH 7.0)-3.48

Net Charge (pH 7.4) -3.72

Charge Density (pH 7.0) -0.1338

GRAVY Index-1.58

Hydrophobic Moment 0.69

Boman Index-0.32

Instability Index71.98

Aliphatic Index 60.00

Aromaticity 0.1154

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1395.14

LogP -7.23

H-bond Donors 48.0

H-bond Acceptors 47.0

Rotatable Bonds 121.0

Heavy Atoms 235.0

Ring Count 5.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0256316 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. Viruses. 2019 Jul 3;11(7):609. doi: 10.3390/v11070609. PMID: 31277353. PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0423045 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 NL4-3 | TZM-bl cells

Activity0.0028±0.0002 μM

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. | Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y. | Viruses. 2019 Jul 3;11(7):609. | DOI:10.3390/v11070609 | PMID:31277353 PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

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