Peptide Database

Peptide NameSLAY-screened peptide P1901

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC88H142N28O26S3

DescriptionStandard

        LWGVSCSPRGNPCRCLGLDA
    

Molecular Weight2104.44 Da

Isoelectric Point (pI)7.97

Net Charge (pH 7.0)0.73

Net Charge (pH 7.4) 0.48

Charge Density (pH 7.0) 0.0366

GRAVY Index0.10

Hydrophobic Moment 0.29

Boman Index0.06

Instability Index46.59

Aliphatic Index 78.00

Aromaticity 0.0500

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 859.08

LogP -10.30

H-bond Donors 33.0

H-bond Acceptors 30.0

Rotatable Bonds 63.0

Heavy Atoms 145.0

Ring Count 4.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0390387 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/