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MYP_121664
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Basic Information
Brevinin-1Pb
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
24 amino acids
C125H204N28O26S2
Standard
Sequence
FLPIIAGIAAKVFPKIFCAISKKC
Physicochemical Analysis
2579.26 Da
9.70
3.74
3.50
0.1557
1.30
0.61
0.43
15.02
126.25
0.1250
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
839.35
-1.70
30.0
32.0
83.0
181.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0342158 VERIFIED: YES
Provenance & Taxonomy
Northern leopard [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial
PMID10333736 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10333736/
RECORD: Rec_0346264 VERIFIED: YES
Provenance & Taxonomy
Lithobates pipiens [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
PaperJ. Goraya et al. / Eur. J. Biochem. 267 (2000) 894-900. Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
RECORD: Rec_0349881 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
14 μM
MIC
PMID10651828;12413397 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
RECORD: Rec_0357205 VERIFIED: NO
Provenance & Taxonomy
Rana pipiens [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0384294 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
7 μM
MIC
PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
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