Peptide Database

Peptide NameSLAY-screened peptide P2041

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC99H157N25O27S2

DescriptionStandard

        NSCPLAPIVRATYTWSIVVC
    

Molecular Weight2193.59 Da

Isoelectric Point (pI)8.06

Net Charge (pH 7.0)0.74

Net Charge (pH 7.4) 0.51

Charge Density (pH 7.0) 0.0370

GRAVY Index0.88

Hydrophobic Moment 0.45

Boman Index0.32

Instability Index24.81

Aliphatic Index 112.00

Aromaticity 0.1000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 820.57

LogP -6.82

H-bond Donors 31.0

H-bond Acceptors 30.0

Rotatable Bonds 62.0

Heavy Atoms 153.0

Ring Count 5.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0185480 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/