Peptide Database

Peptide NameSLAY-screened peptide P2386

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC79H125N25O25S4

DescriptionStandard

        NACCVFAPAPCADRGALGCN
    

Molecular Weight1953.25 Da

Isoelectric Point (pI)5.81

Net Charge (pH 7.0)-0.28

Net Charge (pH 7.4) -0.54

Charge Density (pH 7.0) -0.0139

GRAVY Index0.54

Hydrophobic Moment 0.33

Boman Index0.19

Instability Index36.31

Aliphatic Index 59.00

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 250.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 784.02

LogP -10.86

H-bond Donors 29.0

H-bond Acceptors 29.0

Rotatable Bonds 56.0

Heavy Atoms 133.0

Ring Count 3.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0115970 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/