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MYP_121602
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Basic Information
Css54
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
25 amino acids
C138H221N33O33
Standard
Sequence
FFGSLLSLGSKLLPSVFKLFQRKKE
Physicochemical Analysis
2870.43 Da
10.46
3.76
3.55
0.1506
0.22
0.71
0.10
12.20
105.20
0.1600
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1080.22
-6.42
38.0
37.0
99.0
204.0
5.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0292817 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Toxic Hemolytic Anti-Gram-positive Cytotoxic Anti-Gram-negative
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0318697 VERIFIED: YES
Provenance & Taxonomy
Centruroides suffusus suffusus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Hemolytic Cytolytic
human erythrocytes
83 %
Hemolysis at 25 μM
PaperAntimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics. DOI:10.1038/ja.2012.87 PMID23093034 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23093034/
RECORD: Rec_0319093 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
MeX pooled-growth screened peptide Antimicrobial Antibacterial
Escherichia coli TOP10
9.78 dimensionless OD_ID
MeX pooled growth assay (OD_ID at 4.5 h; Wald-adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0348500 VERIFIED: NO
Provenance & Taxonomy
Centruroides suffusus [Animal]
Cs
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic
PaperJ Antibiot (Tokyo). 2013 Jan;66(1):3-10. | http://www.ncbi.nlm.nih.gov/pubmed/23093034 PMID23093034 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23093034/
RECORD: Rec_0400180 VERIFIED: NO
Provenance & Taxonomy
Centruroides suffusus [Animal]
NDBP
Structure & Mods
non-disulfide-bridged amphipathic peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic
Escherichia coli
PMID23093034;24184590 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23093034/
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