Peptide Database

Peptide NameTP3

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Wound healing/Regeneration ▸ Wound healing

Standard StatusStandard

Sequence Length23 amino acids

Chemical FormulaC117H182N36O25

DescriptionStandard

        FIHHIIGGLISVGKHIHGLIHGH
    

Molecular Weight2492.92 Da

Isoelectric Point (pI)8.79

Net Charge (pH 7.0)1.28

Net Charge (pH 7.4) 0.77

Charge Density (pH 7.0) 0.0557

GRAVY Index0.68

Hydrophobic Moment 0.52

Boman Index0.48

Instability Index52.83

Aliphatic Index 148.26

Aromaticity 0.0435

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 921.85

LogP -4.60

H-bond Donors 32.0

H-bond Acceptors 32.0

Rotatable Bonds 81.0

Heavy Atoms 178.0

Ring Count 7.0

Amide Bonds 22.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0234088 VERIFIED: YES

Provenance & Taxonomy

OrganismOreochromis niloticus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antibacterial Wound healing Immunomodulatory Anti-Gram-positive Antimicrobial Hemolytic

Targetmouse red blood cell

PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/

RECORD: Rec_0270871 VERIFIED: YES

Provenance & Taxonomy

OrganismOreochromis niloticus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antibacterial Wound healing Immunomodulatory Anti-Gram-positive Antimicrobial

TargetStaphylococcus aureus

Activity256 μg/mL

MethodMIC

PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/

FIRST PREV 1 2

Showing 2 records on this page Ã‚Â· Page 2 of 2