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MYP_121580
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Basic Information
TP3
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Wound healing/Regeneration ▸ Wound healing
Standard
23 amino acids
C117H182N36O25
Standard
Sequence
FIHHIIGGLISVGKHIHGLIHGH
Physicochemical Analysis
2492.92 Da
8.79
1.28
0.77
0.0557
0.68
0.52
0.48
52.83
148.26
0.0435
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
921.85
-4.60
32.0
32.0
81.0
178.0
7.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0057694 VERIFIED: NO
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Wound healing Immunomodulatory Anti-Gram-positive Antimicrobial Hemolytic
PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0122334 VERIFIED: YES
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Wound healing Immunomodulatory Anti-Gram-positive Antimicrobial
Candida albicans
128 μg/mL
MIC
PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0151247 VERIFIED: NO
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Wound healing Immunomodulatory Anti-Gram-positive Antimicrobial
PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0174694 VERIFIED: YES
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
MeX pooled-growth screened peptide Antimicrobial Antibacterial
Escherichia coli TOP10
4.74 dimensionless OD_ID
MeX pooled growth assay (OD_ID at 4.5 h; Wald-adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0193901 VERIFIED: YES
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Wound healing Immunomodulatory Anti-Gram-positive Antimicrobial
Methicillin-resistant Staphylococcus aureus
256 μg/mL
MIC
PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
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