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MYP_121532
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Basic Information
BPC622
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
10 amino acids
C62H113N17O12
Standard
Sequence
KKLKKFKKLQ
Physicochemical Analysis
1288.67 Da
10.70
5.75
5.54
0.5754
-1.65
0.51
-0.65
1.10
78.00
0.1000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
524.43
-1.86
18.0
18.0
52.0
91.0
1.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0276828 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
MDA-MB-231 (70 ± 0.01% Growth inhibition=40 μM
32.5±0.5 μM
IC50
PaperAntimicrobial cyclic decapeptides with anticancer activity. Peptides. 2010 Nov;31(11):2017-26. doi: 10.1016/j.peptides.2010.07.027. PMID: 20708052. PMID20708052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20708052/
RECORD: Rec_0276860 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Cyclolipopeptides with a D-Phe
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Fusarium oxysporum
3.1-6.2
MIC
PMID27008420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27008420/
RECORD: Rec_0277573 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
butanoyl
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
X. axonopodis
3.1-6.2
MIC
PMID27008420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27008420/
RECORD: Rec_0278537 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
octanoyl
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Pseudomonas syringae pv. syringae
PMID23563492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23563492/
RECORD: Rec_0283135 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Hemolytic
human red blood cells
150 μM
Hemolysis
PMID27008420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27008420/
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