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MYP_121448
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
3 amino acids
C18H38N12O4
Standard
Sequence
RRR
Physicochemical Analysis
486.57 Da
12.00
2.76
2.56
0.9200
-4.50
0.55
-2.53
388.53
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
307.22
-3.84
13.0
7.0
17.0
34.0
0.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0229362 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Polyarginine
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Conjugation with TMR
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID22465335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22465335/
RECORD: Rec_0240418 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Polyarginine
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
EGFP fusion
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID22465335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22465335/
RECORD: Rec_0281957 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperQuantitative structure-activity relationship study of bitter di- and tri-peptides including relationship with angiotensin I-converting enzyme inhibitory activity. PMID17117396 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17117396/
RECORD: Rec_0293060 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Angiotensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
Angiotensin-converting enzyme
59 μM
IC50
RECORD: Rec_0322671 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
PaperBonnard V., Pascale L., Azoulay S., Di Giorgio A., Rogez-Kreuz C., Storck K., Clayette P., Patino N.. Polyamide amino acids trimers as TAR RNA ligands and anti-HIV agents. Bioorg. Med. Chem., 18, 7432-7438, 2010.
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