Peptide Database

Peptide NamefsANP

Function Ontology

Natriuretic

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC188H302N66O57S3

DescriptionStandard

        SLRRSSCFGGRMDRIGAQSGLGCNSFRYRITAREDKQGWA
    

Molecular Weight4495.01 Da

Isoelectric Point (pI)10.73

Net Charge (pH 7.0)4.44

Net Charge (pH 7.4) 4.20

Charge Density (pH 7.0) 0.1111

GRAVY Index-0.78

Hydrophobic Moment 0.60

Boman Index-0.27

Instability Index64.72

Aliphatic Index 46.50

Aromaticity 0.1000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2056.11

LogP -27.36

H-bond Donors 79.0

H-bond Acceptors 65.0

Rotatable Bonds 153.0

Heavy Atoms 314.0

Ring Count 5.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0391229 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyNatriuretic peptide

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide7-23

Bio-Activity Profile

Function

Natriuretic

Activity0.0032 μM

MethodIC50

Half-LifeHuman kidney membranes, in vitro; 270 s