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MYP_121360
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Basic Information
DC3
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C129H217N37O44S6
Standard
Sequence
GTSCGETCVLLPCLSSVLGCTCQNKRCYKD
Physicochemical Analysis
3182.71 Da
7.77
0.70
0.41
0.0235
0.12
0.35
0.02
56.54
71.33
0.0333
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1314.76
-18.00
52.0
51.0
104.0
216.0
2.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0032148 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Psyle E. Mol. Wt: 3176.7; GRAVY=0.12. Kill human prostate cancer cells: LNcap
0.21 μM
IC50
PaperNovel cyclotides from Hedyotis diffusa induce apoptosis and inhibit proliferation and migration of prostate cancer cells
RECORD: Rec_0039297 VERIFIED: YES
Provenance & Taxonomy
Melicytus chathamicus [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0041712 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
DU145
0.55 μM
IC50
PaperPubMed PMID: 26064310 PMID26064310 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26064310/
RECORD: Rec_0073796 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 26064310 PMID26064310 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26064310/
RECORD: Rec_0102497 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Anticancer Cytotoxic
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