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MYP_121330
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Basic Information
Rugosin-B
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
33 amino acids
C159H264N42O43S2
Standard
Sequence
SLFSLIKAGAKFLGKNLLKQGAQYAACKVSKEC
Physicochemical Analysis
3516.18 Da
9.70
4.44
4.19
0.1344
0.15
0.60
0.08
32.95
94.85
0.0909
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1398.13
-12.85
50.0
50.0
124.0
246.0
3.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0222481 VERIFIED: NO
Provenance & Taxonomy
Glandirana rugosa [Animal]
Frog skin active peptide (FSAP)
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Non-ribosomal
Gram-negative bacteria; Gram-positive bacteria
Qualitative functional evidence
PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/; https://www.uniprot.org/uniprotkb/P80955/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0248335 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus 209P
6.25 μg/mL
MIC
PaperIsolation and characterization of novel antimicrobial peptides, rugosins A, B and C, from the skin of the frog, Rana rugosa.
RECORD: Rec_0249991 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Rugosin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis ATCC 6633
6.25 μg/mL
MIC
PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/
RECORD: Rec_0265142 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus ATCC9341
1.56 μg/mL
MIC
PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/
RECORD: Rec_0284789 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Rugosin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus pyogenes COOK
12.5 μg/mL
MIC
PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/
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