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MYP_121330
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Basic Information
Rugosin-B
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
33 amino acids
C159H264N42O43S2
Standard
Sequence
SLFSLIKAGAKFLGKNLLKQGAQYAACKVSKEC
Physicochemical Analysis
3516.18 Da
9.70
4.44
4.19
0.1344
0.15
0.60
0.08
32.95
94.85
0.0909
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1398.13
-12.85
50.0
50.0
124.0
246.0
3.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0108489 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0154665 VERIFIED: YES
Provenance & Taxonomy
Japanese wrinkled [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/
RECORD: Rec_0181100 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
Escherichia coli NIHJ
12.5 μg/mL
MIC
PaperIsolation and characterization of novel antimicrobial peptides, rugosins A, B and C, from the skin of the frog, Rana rugosa.
RECORD: Rec_0193118 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Rugosin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial
PaperH-S. Won et al. / Biochimica et Biophysica Acta 1788 (2009) 1620-1629. Action mechanism and structural requirements of the antimicrobial peptides, gaegurins Evidence URLhttps://www.uniprot.org/uniprotkb/P80955/entry
RECORD: Rec_0220749 VERIFIED: NO
Provenance & Taxonomy
Rana rugosa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
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