Peptide Database

Peptide NameSLAY-screened peptide P223

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC89H127N19O30S2

DescriptionStandard

        YSGTYTGFSNYCIVDCTI
    

Molecular Weight2007.20 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.26

Net Charge (pH 7.4) -1.50

Charge Density (pH 7.0) -0.0701

GRAVY Index0.31

Hydrophobic Moment 0.20

Boman Index0.29

Instability Index0.34

Aliphatic Index 59.44

Aromaticity 0.2222

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4595.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 800.25

LogP -8.92

H-bond Donors 31.0

H-bond Acceptors 31.0

Rotatable Bonds 59.0

Heavy Atoms 140.0

Ring Count 4.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0049730 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/