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MYP_121215
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Basic Information
Cyclotide Cter M
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C128H200N32O42S7
Standard
Sequence
GLPTCGETCTLGTCYVPDCSCSWPICMKN
Physicochemical Analysis
3083.60 Da
4.37
-1.30
-1.59
-0.0447
0.21
0.20
0.18
48.53
50.34
0.0690
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1152.86
-13.96
45.0
48.0
91.0
209.0
6.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0298473 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Insecticidal Hemolytic Nematocidal Anthelmintic Anti-Gram-negative
Pseudomonas aeruginosa
100 μM
MIC
PaperPlant antimicrobial peptides as potential anticancer agents | PubMed PMID 21596750 | Serra et al., 2016 | Gilding et al., 2016 PMID21596750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21596750/
RECORD: Rec_0299877 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Insecticidal Hemolytic Nematocidal Anthelmintic Anti-Gram-positive
Staphylococcus aureus
100 μM
MIC
PaperPlant antimicrobial peptides as potential anticancer agents | PubMed PMID 21596750 | Serra et al., 2016 | Gilding et al., 2016 PMID21596750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21596750/
RECORD: Rec_0300161 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
cyclotide family
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-19; 9-21; 14-26
27-Met: Methionine sulfoxide
Bio-Activity Profile
Antimicrobial cyclotide family Host defense
PaperPDB 2LAM structural record; NMR; chain A; residues 1-29
RECORD: Rec_0308935 VERIFIED: NO
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
disulfide-stabilized; exact pairings not extracted
cystine-knot scaffold
Bio-Activity Profile
Anticancer Antimicrobial
PaperPlant Antimicrobial Oligopeptides with Anticancer Properties as a Source of Biologically Active Peptides—An In Silico Study PMID41009751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/41009751/
RECORD: Rec_0317206 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Hemolytic
human type A erythrocytes
PaperPubMed PMID: 21596752 PMID21596752 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21596752/
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