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MYP_121070
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Basic Information
Defensin MT3
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Standard
38 amino acids
C197H306N64O48S6
Standard
Sequence
GYYCPFRQDKCHRHCRSFGRKAGYCGNFLKRTCICVKK
Physicochemical Analysis
4531.33 Da
9.75
8.87
8.46
0.2334
-0.78
0.80
-0.30
49.18
30.79
0.1579
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1852.82
-18.83
74.0
65.0
150.0
315.0
9.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0312360 VERIFIED: YES
Provenance & Taxonomy
Ixodes ricinus [Animal]
DefM
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic
PaperDev Comp Immunol. 2015 Dec;53(2):358-65. | https://www.ncbi.nlm.nih.gov/pubmed/26255244 PMID26255244 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26255244/
RECORD: Rec_0329972 VERIFIED: YES
Provenance & Taxonomy
Ixodes ricinus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic
Staphylococcus aureus
60 μM
MIC
PaperIxodes ricinus defensins attack distantly-related pathogens.
RECORD: Rec_0337055 VERIFIED: YES
Provenance & Taxonomy
Ixodes ricinus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Listeria grayi DSM 20601
8 μM
MIC
PMID26255244;27822206 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26255244/
RECORD: Rec_0362354 VERIFIED: YES
Provenance & Taxonomy
Ixodes ricinus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Listeria innocua DSM 20649
PMID26255244;27822206 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26255244/
RECORD: Rec_0394184 VERIFIED: YES
Provenance & Taxonomy
Ixodes ricinus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Plasmodium falciparum[50-60% Inhibition = 50 microM]
PMID26255244;27822206 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26255244/
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