Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length184 amino acids

Chemical FormulaC932H1472N254O253S6

DescriptionStandard

        PKTLPMAHEPMLLLAVTELVANSAAFTYFTAGALRRNFSSDMLPRQFPFQLRTKSMEAFSPQLQEHYPDQPVELHLWARRQPLLSCHPDALHGTLFSSAEAFVVLPNATRVPIFLLNIDANVTGKPTITRNRLGGTVRLTGLVPDPELALPVPQVKRLETLLKFGLWLFGVPRANSESCPRLSP
    

Molecular Weight20475.60 Da

Isoelectric Point (pI)9.46

Net Charge (pH 7.0)4.40

Net Charge (pH 7.4) 4.03

Charge Density (pH 7.0) 0.0239

GRAVY Index-0.02

Hydrophobic Moment 0.54

Boman Index0.08

Instability Index59.39

Aliphatic Index 95.43

Aromaticity 0.0815

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7968.84

LogP -89.87

H-bond Donors 273.0

H-bond Acceptors 268.0

Rotatable Bonds 646.0

Heavy Atoms 1445.0

Ring Count 42.0

Amide Bonds 197.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0077884 VERIFIED: NO

Provenance & Taxonomy

OrganismGrantiella picta [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria