Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length283 amino acids

Chemical FormulaC1425H2235N355O398S12

DescriptionStandard

        VESICKVVTDSVSSKLQPYFQNLPVMAKIDAVAGIDYRLVAPPTATSEYLDGHLKGEFFSLAHHIPPPFAPSALEVPADHDRMVYMGLSEYFFNTAGLVYYKAGALKLTLTDETIPKNSTIRLTTRFFGTFLPQVAEMFPNMNMQIVISVSTPPHLSMQSSGLALTPYLEAETFAILPNSSLASLFLLGLSTNASVELGTMSSRLVGELKLDRLLLELKHSNIGPFPVAPLQAIMDYVVPTLVLPRVNQRLQKGFPLPMPSHVQLYNLMLRSHPGFLLFGADV
    

Molecular Weight31092.91 Da

Isoelectric Point (pI)6.25

Net Charge (pH 7.0)-2.55

Net Charge (pH 7.4) -3.24

Charge Density (pH 7.0) -0.0090

GRAVY Index0.24

Hydrophobic Moment 0.71

Boman Index0.20

Instability Index39.68

Aliphatic Index 103.00

Aromaticity 0.0919

Extinction Coeff. Reduced 14900.00

Extinction Coeff. Oxidized 14900.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0121217 VERIFIED: NO

Provenance & Taxonomy

OrganismProlemur simus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence