Peptide Database

Peptide NameBig endothelin-1

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell-cell communication

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC189H286N48O56S5

DescriptionStandard

        CSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRS
    

Molecular Weight4286.91 Da

Isoelectric Point (pI)5.31

Net Charge (pH 7.0)-2.10

Net Charge (pH 7.4) -2.47

Charge Density (pH 7.0) -0.0553

GRAVY Index0.15

Hydrophobic Moment 0.34

Boman Index0.16

Instability Index59.42

Aliphatic Index 81.84

Aromaticity 0.1053

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1628.85

LogP -14.47

H-bond Donors 60.0

H-bond Acceptors 61.0

Rotatable Bonds 131.0

Heavy Atoms 298.0

Ring Count 10.0

Amide Bonds 38.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0204669 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyEndothelin/sarafotoxin

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide1-15; 3-11

Bio-Activity Profile

Function

Vasoactive Hormone

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