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MYP_121001
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Basic Information
Big endothelin-1
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
38 amino acids
C189H286N48O56S5
Standard
Sequence
CSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRS
Physicochemical Analysis
4286.91 Da
5.31
-2.10
-2.47
-0.0553
0.15
0.34
0.16
59.42
81.84
0.1053
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1628.85
-14.47
60.0
61.0
131.0
298.0
10.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0055865 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Big endothelin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Growth regulation Development regulation Myotropic Receptor modulation ACE inhibitory
Experimental: 24 (t1/2 of hydrolysis) hours; /86400 seconds; Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Big endothelin-1 (Homo sapiens): PMID 7529108 PMID7529108 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7529108/
RECORD: Rec_0059891 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0071315 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Endothelin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Vasoconstricting peptide
Radioimmunoassay and RP-HPLC
Purified ET-1 protein sample, in vitro; 86400 s
PMID7529108 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7529108/
RECORD: Rec_0108106 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Big endothelin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Growth regulation Development regulation Myotropic Receptor modulation ACE inhibitory
glomerular mesangial cells
Experimental: 24 (t1/2 of hydrolysis) hours; /86400 seconds; Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Big endothelin-1 (Homo sapiens): PMID 7529108 PMID7529108 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7529108/
RECORD: Rec_0153302 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
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