Peptide Database

Peptide NameUnnamed

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ CaMKII Inhibitory

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC62H113N21O18

DescriptionStandard

        KKALRRAEAVDAL
    

Molecular Weight1440.69 Da

Isoelectric Point (pI)9.99

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.1355

GRAVY Index-0.37

Hydrophobic Moment 0.52

Boman Index-0.31

Instability Index56.55

Aliphatic Index 113.08

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 662.96

LogP -5.83

H-bond Donors 24.0

H-bond Acceptors 20.0

Rotatable Bonds 51.0

Heavy Atoms 101.0

Ring Count 0.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0093635 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAIP

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

CaMKII Inhibitory

TargetCalmodulin-dependent protein kinase II (CaMKII)

Activity1.5 μM

MethodIC50

PaperIshida A., Shigeri Y., Tatsu Y., Uegaki K., Kameshita I., Okuno S., Kitani T., Yumoto N., Fujisawa H.. Critical amino acid residues of AIP, a highly specific inhibitory peptide of calmodulin-dependent protein kinase II. FEBS Lett., 427, 115-118. PMID9613610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9613610/