Peptide Database

Peptide NameeapD signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory expression optimization

Enzyme / Catalytic activity ▸ Hydrolase ▸ Protease/Peptidase

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC113H203N27O31S3

DescriptionStandard

        MKKLLTVMTMAVLTAGTLLLPAQS
    

Molecular Weight2532.18 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)1.50

Net Charge (pH 7.4) 1.28

Charge Density (pH 7.0) 0.0624

GRAVY Index1.06

Hydrophobic Moment 0.41

Boman Index0.36

Instability Index40.81

Aliphatic Index 134.17

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 920.11

LogP -6.37

H-bond Donors 32.0

H-bond Acceptors 36.0

Rotatable Bonds 85.0

Heavy Atoms 174.0

Ring Count 1.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0353502 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis [Bacterium]

FamilySec signal peptide

Tax ID1423

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Aminopeptidase (AP) secretion

TargetBacillus subtilis WB600

Activity73.6 U/mL

MethodAminopeptidase activity assay

PaperGuan C, Cui W, Cheng J, et al. Construction of a highly active secretory expression system via an engineered dual promoter and a highly efficient signal peptide in Bacillus subtilis[J]. New Biotechnology, 2016, 33(3): 372-379. PMID26820123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26820123/