Peptide Database

Peptide NameGranulysin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium

Antimicrobial ▸ Antifungal

Antiparasitic ▸ Antiprotozoal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Standard StatusStandard

Sequence Length123 amino acids

Chemical FormulaC598H991N191O184S9

DescriptionStandard

        RLSPEYYDLARAHLRDEEKSCPCLAQEGPQGDLLTKTQELGRDYRTCLTIVQKLKKMVDKPTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQGLVAGETAQQICEDLRLCIPSTGPL
    

Molecular Weight14089.02 Da

Isoelectric Point (pI)9.39

Net Charge (pH 7.0)7.80

Net Charge (pH 7.4) 7.41

Charge Density (pH 7.0) 0.0634

GRAVY Index-0.72

Hydrophobic Moment 0.86

Boman Index-0.26

Instability Index52.70

Aliphatic Index 72.93

Aromaticity 0.0488

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11835.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6172.79

LogP -71.53

H-bond Donors 227.0

H-bond Acceptors 202.0

Rotatable Bonds 476.0

Heavy Atoms 982.0

Ring Count 14.0

Amide Bonds 133.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0149546 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606; 0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide47-110; 74-85

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Host defense

RECORD: Rec_0219097 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGranulysin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antimycobacterial

TargetMycobacterium tuberculosis

MethodMIC

RECORD: Rec_0395507 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative

TargetMycobacterium tuberculosis