Peptide Database

Peptide Namefragment of beta-amyloid protein:12-28

Function Ontology

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC89H135N25O25

DescriptionStandard

        VHHQKLVFFAEDVGSNK
    

Molecular Weight1955.18 Da

Isoelectric Point (pI)6.89

Net Charge (pH 7.0)-0.09

Net Charge (pH 7.4) -0.41

Charge Density (pH 7.0) -0.0053

GRAVY Index-0.33

Hydrophobic Moment 0.39

Boman Index0.03

Instability Index24.68

Aliphatic Index 80.00

Aromaticity 0.1176

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 819.33

LogP -7.03

H-bond Donors 27.0

H-bond Acceptors 27.0

Rotatable Bonds 65.0

Heavy Atoms 139.0

Ring Count 4.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0243830 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

PaperCasta?o J. M., Ghiso J., Prelli F., Gorevic P. D., Migheli A., Frangione B.. In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease beta-protein. Biochem. Biophys. Res. Commun., 141, 782-789, 1986. Evidence URLhttps://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL4074607/