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MYP_120906
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Basic Information
Signiferin-3.1
Antimicrobial
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
13 amino acids
C68H108N16O19
Standard
Sequence
GIAEFLNYIKSKA
Physicochemical Analysis
1453.68 Da
8.50
0.76
0.55
0.0585
0.15
0.51
0.18
-3.83
105.38
0.1538
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
585.41
-3.79
20.0
20.0
49.0
103.0
2.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0017160 VERIFIED: YES
Provenance & Taxonomy
Crinia riparia [Animal]
Signiferin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
nNOS inhibitor
PaperR.J. Jackway et al. / Regulatory Peptides 151 (2008) 80-87. Disulfide-containing peptides from the glandular skin secretions of froglets of the genus Crinia: structure, activity and evolutionary trends Evidence URLhttps://www.uniprot.org/uniprotkb/P86128/entry
RECORD: Rec_0074975 VERIFIED: YES
Provenance & Taxonomy
Crinia signifera [Animal]
Signiferin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
nNOS inhibitor
PaperV.M. Maselli et al. / Rapid Communications in Mass Spectrometry 20 (2006) 797-803. Host-defence skin peptides of the Australian Streambank Froglet Crinia riparia: isolation and sequence determination by positive and negative ion electrospray mass spectrometry Evidence URLhttps://www.uniprot.org/uniprotkb/P86135/entry
RECORD: Rec_0092198 VERIFIED: NO
Provenance & Taxonomy
Crinia signifera [Animal]; Crinia riparia [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Enzyme inhibitory
RECORD: Rec_0218788 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 61.5%, E 0.0%, T 7.7%, C 30.8% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/