Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length492 amino acids

Chemical FormulaC2489H3893N621O722S20

DescriptionStandard

        MCSKMAQVLWGCLLLWNLHISPAYSMYPGIKARATQRALDYGVQVGMEIIEQMVKKRDIPNLNGSESLEFLKVDYVNYNFTNIKINAFSFPNTSLAFVPGVGIRALTNHGTANISTDWEIKSPLFRDTGGADLFLSEVYFTGNVILTRNNFGHPILKLQDCHAQVSHADVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPMVTSEVEALNANLSMLEVITKIDNYTLLDYSLISSPDITENYIELYLKGVFYPLGNLTDPPFSSVPFVLPDRSDSMLYIGISEYFFKSASYAYFTAGAFNITLSTKEITDHLIRTSQGLGNMLSRIAELYILSQPFMVRVMATEPPLINLLPGNFTLDIPASIMILTQSKNSTAETIVSMDFVASTDVALVILGQRLICSLSLNVLRFENILSSILHFGILPLANAKLQQGLPLPNPHKISLVNSDIEVLEGFLLISTDLKYETSLKQQPSFHGWESLNLISGQWRGKPAP
    

Molecular Weight54709.56 Da

Isoelectric Point (pI)5.27

Net Charge (pH 7.0)-11.71

Net Charge (pH 7.4) -12.57

Charge Density (pH 7.0) -0.0238

GRAVY Index0.16

Hydrophobic Moment 0.67

Boman Index0.18

Instability Index39.14

Aliphatic Index 105.43

Aromaticity 0.0976

Extinction Coeff. Reduced 54320.00

Extinction Coeff. Oxidized 54570.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0207946 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyBPI/LBP

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence