Peptide Database

Peptide NameDeoxynucleoside triphosphate triphosphohydrolase SAMHD1

Function Ontology

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Standard StatusStandard

Sequence Length626 amino acids

Chemical FormulaC3227H5050N892O941S25

DescriptionStandard

        MQRADSEQPSKRPRCDDSPRTPSNTPSAEADWSPGLELHPDYKTWGPEQVCSFLRRGGFEEPVLLKNIRENEITGALLPCLDESRFENLGVSSLGERKKLLSYIQRLVQIHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESPVEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWNDSTSVQNPTRLREASKSRVQLFKDDPM
    

Molecular Weight72199.65 Da

Isoelectric Point (pI)6.69

Net Charge (pH 7.0)-1.87

Net Charge (pH 7.4) -3.45

Charge Density (pH 7.0) -0.0030

GRAVY Index-0.53

Hydrophobic Moment 0.79

Boman Index-0.08

Instability Index35.04

Aliphatic Index 83.61

Aromaticity 0.0927

Extinction Coeff. Reduced 75750.00

Extinction Coeff. Oxidized 76500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0338051 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilySAMHD1

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

Bio-Activity Profile

Function

Antiviral Replication inhibitor Transcription regulator Anti-HIV-1

TargetHuman immunodeficiency virus type 1(HIV-1)