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MYP_120779
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Basic Information
(rR)2R4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
8 amino acids
C48H98N32O9
Standard
Sequence
RRRRRRRR
Physicochemical Analysis
1267.50 Da
12.00
7.76
7.56
0.9700
-4.50
0.27
-2.53
509.95
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
762.22
-10.10
33.0
17.0
47.0
89.0
0.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0143513 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Oligoarginine/Polycationic
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
Fluorophore labeling
C-term detail: Labelled at the C-terminal cysteine using Alexa Fl; lowercase source residues at positions 1,2,3,4,5,6,7,8 denote stereochemical modification
Bio-Activity Profile
Cell-penetrating peptide
KG1a cells
Fluorescence-based uptake assay
PMID17217340 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17217340/
RECORD: Rec_0147579 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: Daunorubicine
Bio-Activity Profile
Anticancer
HL-60
PaperSynthesis of daunomycin-oligoarginine conjugates and their effect on human leukemia cells (HL-60) Evidence URLhttps://doi.org/10.3998/ark.5550190.0009.313
RECORD: Rec_0174768 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Polyarginine
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Stearylation
None
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID23860186 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23860186/
RECORD: Rec_0175921 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive bacteria: Staphylococcus aureus(ATCC 33591)
44 μM
MIC
PMID23085001 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23085001/
RECORD: Rec_0179910 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Polyarginine
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Conjugated to Radiolabeled cytochrome c with disulphide linkage
Disulfide linkage reported; exact peptide-internal sites not specified
Conjugated to Radiolabeled cytochrome c with disulphide linkage
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID22225540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22225540/
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