‹ ›
MYP_120779
← PREVIOUS NEXT → BACK
Basic Information
(rR)2R4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
8 amino acids
C48H98N32O9
Standard
Sequence
RRRRRRRR
Physicochemical Analysis
1267.50 Da
12.00
7.76
7.56
0.9700
-4.50
0.27
-2.53
509.95
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
762.22
-10.10
33.0
17.0
47.0
89.0
0.0
7.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0353897 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Polyarginine
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID24901376 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24901376/
RECORD: Rec_0357665 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: other; Conjugated small molecule: (8S,10S)-10-[(3-amino-2,3,6-trideoxy-¦Á-L-lyxo-hexopyranosyl)oxy]-8-(1-hydrazonoethyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-Naphthacenedione
Bio-Activity Profile
Anticancer
PaperNew daunomycin¨Coligoarginine conjugates: Synthesis, characterization, and effect on human leukemia and human hepatoma cells Evidence URLhttps://doi.org/10.1002/bip.21264
RECORD: Rec_0358284 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oligoarginine/Polycationic
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Fluorescein/FITC labeling
None
N-term detail: Labelled with fluorescein with aminohexanoic space; lowercase source residues at positions 1,2,3,4,5,6,7,8 denote stereochemical modification
Bio-Activity Profile
Cell-penetrating peptide
Jurkat
Fluorescence-based uptake assay
PMID11087855 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087855/
RECORD: Rec_0368013 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Palustrin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis ATCC 6633[0-10% Inhibition = 10-30 microM]
PMID24243601;26922474 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24243601/
RECORD: Rec_0376900 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Protease inhibitor
Human cytomegalovirus (Furin); CHO
0.061 μM
Ki
PaperPolyarginines are potent furin inhibitors. | Cameron A, Appel J, Houghten RA, Lindberg I. | J Biol Chem. 2000 | PMID:10958789 PMID10958789 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10958789/
FIRST PREV 1 ... 8 9 10 11 12 NEXT LAST
Showing 5 records on this page · Page 10 of 12