Peptide Database

Peptide NameSLAY-screened peptide P4581

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H156N28O35S2

DescriptionStandard

        SGRLLHRLSTDLTDDYYDCM
    

Molecular Weight2374.61 Da

Isoelectric Point (pI)4.56

Net Charge (pH 7.0)-2.46

Net Charge (pH 7.4) -2.74

Charge Density (pH 7.0) -0.1230

GRAVY Index-0.63

Hydrophobic Moment 0.73

Boman Index-0.17

Instability Index43.81

Aliphatic Index 78.00

Aromaticity 0.1000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1039.28

LogP -10.86

H-bond Donors 39.0

H-bond Acceptors 36.0

Rotatable Bonds 77.0

Heavy Atoms 165.0

Ring Count 3.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0252579 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/