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MYP_120676
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Antiviral ▸ Virucidal activity
Standard
18 amino acids
C109H155N25O29S
Standard
Sequence
KFDSLVECIWDWIDRLWS
Physicochemical Analysis
2311.61 Da
4.23
-2.24
-2.47
-0.1247
-0.03
0.75
0.11
60.38
102.78
0.2222
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
882.97
-2.51
33.0
28.0
72.0
164.0
7.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0182213 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Release inhibition
Hepatitis C virus (HCV) | Huh-7.5.1 cells
0.85 μM
IC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperA virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro. | Cheng G, Montero A, Gastaminza P, Whitten-Bauer C, Wieland SF, Isogawa M, Fredericksen B, Selvarajah S, Gallay PA, Ghadiri MR, Chisari FV. | Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-93. | DOI:10.1073/pnas.0712380105 | PMID:18287023 PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0232566 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antiviral
Hepatitis C virus HCV JFH-1
PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0288095 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperA virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-3093. doi: 10.1073/pnas.0712380105. PMID: 18287023. PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0312956 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Hepatitis C virus(HCV):inhibition of HCV infection in Huh-7
PaperA virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-3093. doi: 10.1073/pnas.0712380105. PMID: 18287023. PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0410261 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antiviral
Hepatitis C virus HCV JFH-1
0.48 μM
IC50
PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
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