Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length467 amino acids

Chemical FormulaC2392H3788N602O654S18

DescriptionStandard

        MAWGPDNVRKWSSLALLAIVGTALTAATDPGFVARISQKGLDFVCQESMVELQKELLAISIPDFSGDFKIKHLGKGTYEFYSMAVEGFHIPDPQIKLLPSDGLQLSITSASIKISGRWKYRKNILKASGNFQLSIQGVSIIADLILGNDPSGRITITCSTCDSHINSVRIKVSGSMLGWLIQLFHRKIETSLKKTIYKKICKIVRNSVSAKLQPYVKTLPVVAKVDDITSIDYSLLAPPMTTDKFLEGQLRGEFFWRGHHGPFPAVPPVMNILPNNNYMVCMGISDYFFNTAEFAYQESETLKITLRDQLLAKDARYHLNTDFLKTFLPEVAKKFPSMGLQLLISAPLFAHLNIQPSGLSLSPNLETRAFVVLPNSSLIPLFLLGMKTNASLEVNLLPFPPLPPFHLQVELLEDVINYLMSTMVLPKINEKLRRGFPLPLPAGIQLINSILYSSQTGLFLLLYAYML
    

Molecular Weight52020.47 Da

Isoelectric Point (pI)9.12

Net Charge (pH 7.0)9.26

Net Charge (pH 7.4) 8.41

Charge Density (pH 7.0) 0.0198

GRAVY Index0.17

Hydrophobic Moment 0.86

Boman Index0.16

Instability Index40.18

Aliphatic Index 108.16

Aromaticity 0.0942

Extinction Coeff. Reduced 48360.00

Extinction Coeff. Oxidized 48610.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0192166 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyBPI/LBP

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria