Peptide Database

Peptide NameSLAY-screened peptide P3639

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC58H90N12O17S2

DescriptionStandard

        MDPLWADSMLL
    

Molecular Weight1291.54 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-2.50

Net Charge (pH 7.4) -2.71

Charge Density (pH 7.0) -0.2270

GRAVY Index0.61

Hydrophobic Moment 0.09

Boman Index0.37

Instability Index26.75

Aliphatic Index 115.45

Aromaticity 0.0909

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 456.15

LogP -0.92

H-bond Donors 15.0

H-bond Acceptors 17.0

Rotatable Bonds 39.0

Heavy Atoms 89.0

Ring Count 3.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0407430 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/