Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length187 amino acids

Chemical FormulaC927H1440N238O262S7

DescriptionStandard

        MLPSVMVVFAILSCTRGKNPAVQVTLTDKWLQYVKHVGAGWIQDKLEHITFPDISGDVDILIGHVYYTLSGIRITKCDLPEPVLEFFQSTGLKTSIVGLNAALVGNWRTSFGIIHDGGSFDMAIFSVSLTSMVQLGRDPDGHLSITSIGCEPQVGNVAIQFHGGASFIFQPFVDHFKGKIVSVIQSN
    

Molecular Weight20335.24 Da

Isoelectric Point (pI)6.12

Net Charge (pH 7.0)-2.91

Net Charge (pH 7.4) -3.55

Charge Density (pH 7.0) -0.0155

GRAVY Index0.32

Hydrophobic Moment 0.58

Boman Index0.24

Instability Index26.04

Aliphatic Index 102.57

Aromaticity 0.0963

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 21095.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7879.15

LogP -87.49

H-bond Donors 272.0

H-bond Acceptors 273.0

Rotatable Bonds 661.0

Heavy Atoms 1434.0

Ring Count 36.0

Amide Bonds 200.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0404083 VERIFIED: NO

Provenance & Taxonomy

OrganismNothobranchius pienaari [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria