Peptide Database

Peptide NameMCoTI-I

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC137H227N49O47S6

DescriptionStandard

        GGVCPKILQRCRRDSDCPGACICRGNGYCGSGSD
    

Molecular Weight3504.96 Da

Isoelectric Point (pI)8.34

Net Charge (pH 7.0)1.71

Net Charge (pH 7.4) 1.41

Charge Density (pH 7.0) 0.0502

GRAVY Index-0.45

Hydrophobic Moment 0.68

Boman Index-0.16

Instability Index58.45

Aliphatic Index 45.88

Aromaticity 0.0294

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1558.66

LogP -24.11

H-bond Donors 61.0

H-bond Acceptors 55.0

Rotatable Bonds 114.0

Heavy Atoms 239.0

Ring Count 3.0

Amide Bonds 35.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0389712 VERIFIED: YES

Provenance & Taxonomy

OrganismMomordica cochinchinensis [Plant]

Structure & Mods

Confighead-to-tail cyclic cyclotide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide4-21; 11-23; 17-29

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetU-937/GTB

Activity>32 μM

MethodIC50

RECORD: Rec_0420951 VERIFIED: NO