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MYP_120527
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Basic Information
Cyclotide mela-6
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
29 amino acids
C131H205N33O41S6
Standard
Sequence
GLPTCGETCFKGKCYTPGCSCSYPICKKD
Physicochemical Analysis
3090.62 Da
8.31
1.70
1.40
0.0587
-0.32
0.39
0.00
15.23
26.90
0.1034
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1172.04
-14.19
46.0
49.0
96.0
211.0
6.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0055950 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
5-19; 9-21; 14-26
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Anti-Gram-positive
Staphylococcus aureus
Qualitative functional evidence
PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
RECORD: Rec_0114160 VERIFIED: NO
Provenance & Taxonomy
Melicytus latifolius [Plant]
Structure & Mods
head-to-tail cyclic cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
5-19; 9-21; 14-26
Bio-Activity Profile
Anticancer
PMID26322745
RECORD: Rec_0210661 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-19; 9-21; 14-26
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
11.42±1 μM
IC50
PaperPubMed PMID: 26322745 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
RECORD: Rec_0236410 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-19; 9-21; 14-26
Bio-Activity Profile
Antimicrobial Anticancer
MM96L
1.58±0.48 μM
CC50
PaperPubMed PMID: 26322745 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
RECORD: Rec_0248583 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
5-19; 9-21; 14-26
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic
Human cervical carcinoma HeLa
11.42±1.00 μM
IC50
PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
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