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MYP_120415
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Basic Information
Agelaia-mastoparan (Agelaia-MP; Insects, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
14 amino acids
C75H126N18O18
Standard
Sequence
INWLKLGKAIIDAL
Physicochemical Analysis
1567.91 Da
8.59
0.76
0.55
0.0542
0.89
0.59
0.37
-7.50
181.43
0.0714
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
589.84
-1.02
20.0
19.0
53.0
111.0
2.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0091023 VERIFIED: YES
Provenance & Taxonomy
Agelaia pallipes pallipes [Animal]
MCD; Mastoparan subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiofilm Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic
Acinetobacter baumannii
PMID15052574;15225564;30974767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15052574/
RECORD: Rec_0128218 VERIFIED: YES
Provenance & Taxonomy
Agelaia pallipes pallipes [Animal]
Mastoparan
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-negative
Acinetobacter baumannii Isolate AB 02
25 μM
MIC
PMID30974767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30974767/
RECORD: Rec_0146360 VERIFIED: YES
Provenance & Taxonomy
Agelaia pallipes pallipes [Animal]
Mastoparan
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-negative
Acinetobacter baumannii Isolate AB 72
12.5 μM
MIC
PMID30974767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30974767/
RECORD: Rec_0159238 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0177353 VERIFIED: YES
Provenance & Taxonomy
Agelaia pallipes pallipes [Animal]
Mastoparan
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-negative
Acinetobacter baumannii Isolate AB 53
6.25 μM
MIC
PMID30974767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30974767/
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