Peptide Database

Peptide NameSLAY-screened peptide P357

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC114H172N36O28S2

DescriptionStandard

        RENRPSHWFVTQLCYLLCRH
    

Molecular Weight2558.94 Da

Isoelectric Point (pI)8.96

Net Charge (pH 7.0)1.92

Net Charge (pH 7.4) 1.58

Charge Density (pH 7.0) 0.0958

GRAVY Index-0.61

Hydrophobic Moment 0.53

Boman Index-0.19

Instability Index28.93

Aliphatic Index 73.00

Aromaticity 0.1500

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1050.45

LogP -8.22

H-bond Donors 40.0

H-bond Acceptors 34.0

Rotatable Bonds 79.0

Heavy Atoms 180.0

Ring Count 7.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0378626 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/