Peptide Database

Peptide NameSLAY-screened peptide P2292

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC111H161N29O31S

DescriptionStandard

        NNSTWDHPSHNIVGVLIFMFT
    

Molecular Weight2429.71 Da

Isoelectric Point (pI)5.97

Net Charge (pH 7.0)-1.06

Net Charge (pH 7.4) -1.37

Charge Density (pH 7.0) -0.0507

GRAVY Index0.11

Hydrophobic Moment 0.33

Boman Index0.28

Instability Index34.28

Aliphatic Index 83.33

Aromaticity 0.1429

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 957.17

LogP -8.58

H-bond Donors 32.0

H-bond Acceptors 33.0

Rotatable Bonds 73.0

Heavy Atoms 172.0

Ring Count 7.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0130712 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/