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MYP_120339
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Basic Information
C8W->A776
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
8 amino acids
C51H71N13O13
Standard
Sequence
WEDWVRAI
Physicochemical Analysis
1074.19 Da
4.37
-1.24
-1.44
-0.1545
-0.35
0.84
0.07
22.21
97.50
0.2500
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
435.10
-0.44
16.0
12.0
31.0
77.0
4.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0254069 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-FIV Entry inhibition
FIV-M2 (Feline immunodeficiency virus M2) | MBM cells
50 μg/mL
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperAntiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein. | Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M. | J Virol. 2003 Mar;77(6):3724-33. | DOI:10.1128/jvi.77.6.3724-3733.2003 | PMID:12610147 PMID12610147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12610147/
RECORD: Rec_0266152 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-FIV Entry inhibition
FIV-Pet (Feline immunodeficiency virus Pet) | MBM cells
50 μg/mL
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperAntiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein. | Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M. | J Virol. 2003 Mar;77(6):3724-33. | DOI:10.1128/jvi.77.6.3724-3733.2003 | PMID:12610147 PMID12610147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12610147/
RECORD: Rec_0279188 VERIFIED: YES
Provenance & Taxonomy
Feline immunodeficiency virus [Virus]
Virus-derived peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Sequence-variant derivative
Bio-Activity Profile
Antiviral Replication inhibitor
Feline immunodeficiency virus (Replication); MBM
46.546089 μM
ELISA
PaperAntiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein. | Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M. | J Virol. 2003 | PMID:12610147 PMID12610147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12610147/
RECORD: Rec_0286362 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 50.0%, C 50.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0386971 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-FIV Entry inhibition
FIV-GL8 (Feline immunodeficiency virus GL8) | MBM cells
50 μg/mL
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperAntiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein. | Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M. | J Virol. 2003 Mar;77(6):3724-33. | DOI:10.1128/jvi.77.6.3724-3733.2003 | PMID:12610147 PMID12610147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12610147/
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