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MYP_120335
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Basic Information
Citropin-1.1 (Frogs, amphibians, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C76H130N18O20
Standard
Sequence
GLFDVIKKVASVIGGL
Physicochemical Analysis
1615.95 Da
8.59
0.76
0.55
0.0474
1.28
0.64
0.46
14.19
158.12
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
609.39
-3.30
21.0
21.0
55.0
114.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0052821 VERIFIED: YES
Provenance & Taxonomy
Litoria citropa [Animal]
Aurein
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus (ATCC 25923)
3 μM
MIC
PMID31448597 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31448597/
RECORD: Rec_0057323 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Citropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Neuropeptide
PaperDoyle J., Llewellyn L. E., Brinkworth C. S., Bowie J. H., Wegener K. L., Rozek T., Wabnitz P. A., Wallace J. C., Tyler M. J.. Amphibian peptides that inhibit neuronal nitric oxide synthase. Isolation of lesuerin from the skin secretion of the Australian Stony Creek frog Litoria lesueuri. Eur. J. Biochem., 269, 100-109, 2002.
RECORD: Rec_0076007 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli K12
32 μg/mL
MIC
PMID31336137 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31336137/
RECORD: Rec_0079356 VERIFIED: YES
Provenance & Taxonomy
Litoria citropa [Animal]
Citropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Leuconostoc lactis
6 μg/mL
MIC
PMID10504394 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10504394/
RECORD: Rec_0086108 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Acinetobacter baumannii ATCC 19606
16 μg/mL
MIC
PMID30043322 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30043322/
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