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MYP_120335
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Basic Information
Citropin-1.1 (Frogs, amphibians, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ nNOS inhibitor
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C76H130N18O20
Standard
Sequence
GLFDVIKKVASVIGGL
Physicochemical Analysis
1615.95 Da
8.59
0.76
0.55
0.0474
1.28
0.64
0.46
14.19
158.12
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
609.39
-3.30
21.0
21.0
55.0
114.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0256564 VERIFIED: YES
Provenance & Taxonomy
Litoria citropa [Animal]
Aurein
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
mouse red blood cells
16.5±3 μM
Hemolysis
PMID31448597 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31448597/
RECORD: Rec_0257557 VERIFIED: YES
Provenance & Taxonomy
Amphibian skin [Animal]
Citropin
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Melanoma cancer group (NCI)
10 μM
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1. Eur J Biochem. 2003 Mar;270(6):1141-1153. doi: 10.1046/j.1432-1033.2003.03462.x. PMID: 12631273. PMID12631273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0292791 VERIFIED: YES
Provenance & Taxonomy
Amphibian skin [Animal]
Citropin
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Ovarian cancer group (NCI)
10 μM
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1. Eur J Biochem. 2003 Mar;270(6):1141-1153. doi: 10.1046/j.1432-1033.2003.03462.x. PMID: 12631273. PMID12631273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0294182 VERIFIED: YES
Provenance & Taxonomy
Australian blue mountains [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Anti-inflammatory
Listeria innocua
100 μg/mL
MIC
PaperHost defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1.
RECORD: Rec_0294562 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Citropin
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
Colon tumor cell line
5
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1 PMID12631273;9266696 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
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