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MYP_120292
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Basic Information
Urocortin
Antimicrobial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Stress-related neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
40 amino acids
C206H337N61O65
Standard
Sequence
DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV
Physicochemical Analysis
4708.25 Da
5.00
-2.14
-2.40
-0.0535
-0.46
0.78
-0.16
49.09
109.75
0.0500
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2073.66
-20.47
72.0
64.0
158.0
332.0
5.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0241637 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Cell-Cell Communication Antitrypanosomal Neuropeptide
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0244344 VERIFIED: NO
Provenance & Taxonomy
Rattus norvegicus [Animal]
Sauvagine/corticotropin-releasing factor/urotensin I
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Stress-related neuropeptide
RECORD: Rec_0281502 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 85.0%, E 0.0%, T 2.5%, C 12.5% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Drug Delivery Vehicle Blood-Brain Barrier
PaperBrainpeps: the blood-brain barrier peptide database PMID22205159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22205159/
RECORD: Rec_0350888 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hormone-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antitrypanosomal
Trypanosoma brucei clone 221 (procyclic form)
LD50; MTT assay
PaperNeuropeptides kill African trypanosomes by targeting intracellular compartments and inducing autophagic-like cell death PMID19057622 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19057622/
RECORD: Rec_0383970 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Urocortin
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Analgesic Pronociceptive Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Reproductive regulator Growth regulation Development regulation Myotropic Receptor modulation ACE inhibitory Feeding regulator
Mammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Urocortin (Rattus norvegicus): PMID 11416224 PMID11416224 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11416224/
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