‹ ›
MYP_120292
← PREVIOUS NEXT → BACK
Basic Information
Urocortin
Antimicrobial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Stress-related neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
40 amino acids
C206H337N61O65
Standard
Sequence
DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV
Physicochemical Analysis
4708.25 Da
5.00
-2.14
-2.40
-0.0535
-0.46
0.78
-0.16
49.09
109.75
0.0500
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2073.66
-20.47
72.0
64.0
158.0
332.0
5.0
43.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0059701 VERIFIED: NO
Provenance & Taxonomy
Rattus norvegicus [Animal]; Mus musculus [Animal]; Ovis aries [Animal]
10116, 10090, 9940
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone
RECORD: Rec_0115857 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Urocortin
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Analgesic Pronociceptive Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Reproductive regulator Growth regulation Development regulation Myotropic Receptor modulation ACE inhibitory Feeding regulator
Mammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Urocortin (Mus musculus): PMID 12091910 PMID12091910 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12091910/
RECORD: Rec_0116796 VERIFIED: NO
Provenance & Taxonomy
Rattus norvegicus [Animal]
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Bio-Activity Profile
-
RECORD: Rec_0181272 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]
Sauvagine/corticotropin-releasing factor/urotensin I
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Stress-related neuropeptide
RECORD: Rec_0189500 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hormone-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antitrypanosomal
Trypanosoma brucei brucei AnTat 1.1 (blood stage form)
1.1±0.5 μM
LD50; MTT assay
PaperNeuropeptides kill African trypanosomes by targeting intracellular compartments and inducing autophagic-like cell death PMID19057622 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19057622/
1 2 NEXT LAST
Showing 5 records on this page · Page 1 of 2