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MYP_120282
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Basic Information
Gaegurin 5 (1-11)[G3K][A4W][V8W][S10K]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
11 amino acids
C79H115N17O12
Standard
Sequence
FLKWLFKWAKK
Physicochemical Analysis
1494.87 Da
10.48
3.76
3.55
0.3415
-0.22
0.71
0.07
-14.74
80.00
0.3636
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
489.98
2.81
18.0
16.0
49.0
108.0
6.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0130701 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
HCT-116
14.80 μM
IC50
PaperAnticancer activity of undecapeptide analogues derived from antimicrobial peptide, brevinin-1EMa PMID22644847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22644847/
RECORD: Rec_0139245 VERIFIED: NO
Provenance & Taxonomy
Glandirana rugosa [Animal]
Gaegurin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
SK-OV-3
12550 μM
IC50
PaperAnalogues of antimicrobial and anticancer peptide synthesized and produced from Gaegurin 5 Evidence URLhttps://patents.google.com/patent/US8076284B2/en PatentUS8076284B2
RECORD: Rec_0146417 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antimicrobial
A-498
21.48 μM
IC50
PaperAnticancer activity of undecapeptide analogues derived from antimicrobial peptide, brevinin-1EMa PMID22644847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22644847/
RECORD: Rec_0147177 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Gaegurin/Brevinin analogs
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antimicrobial
PC-3 (prostate cancer)
29.1 μM
IC50
PaperAnticancer activity of undecapeptide analogues derived from antimicrobial peptide, brevinin-1EMa | https://pubmed.ncbi.nlm.nih.gov/22644847/ PMID22644847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22644847/
RECORD: Rec_0165140 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Gaegurin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Micrococcus luteus ATCC 10240
3.1 μg/mL
MIC
PMID22644847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22644847/
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