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MYP_120282
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Basic Information
Gaegurin 5 (1-11)[G3K][A4W][V8W][S10K]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
11 amino acids
C79H115N17O12
Standard
Sequence
FLKWLFKWAKK
Physicochemical Analysis
1494.87 Da
10.48
3.76
3.55
0.3415
-0.22
0.71
0.07
-14.74
80.00
0.3636
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
489.98
2.81
18.0
16.0
49.0
108.0
6.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0065727 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Gaegurin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 6538P
6.3 μg/mL
MIC
PMID22644847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22644847/
RECORD: Rec_0082768 VERIFIED: NO
Provenance & Taxonomy
Glandirana rugosa [Animal]
Gaegurin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
PC-3
29100 μM
IC50
PaperNovel analogues of antimicrobial and anticancer peptide synthesized and produced from gaegurin 5 Evidence URLhttps://patents.google.com/patent/WO2007133033A1/en PatentWO2007133033A1
RECORD: Rec_0087567 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin-derived peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
SK-OV-3
12.55 μM
IC50 / MTT-MTS assay
PaperPMID 22644847; PMID 27993125; GA-K4 antitumor undecapeptide studies PMID22644847;27993125 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22644847/
RECORD: Rec_0097336 VERIFIED: YES
Provenance & Taxonomy
Korean wrinkled [Animal]; synthetic construct [Synthetic]
Brevinin
33208; 32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PMID22644847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22644847/
RECORD: Rec_0109689 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
A-549
14.53 μM
IC50
PaperAnticancer activity of undecapeptide analogues derived from antimicrobial peptide, brevinin-1EMa PMID22644847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22644847/
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